- Metallothioneins and their metal binding preferences
- Metallic anticancer complexes and the fight against cancer
- Radiopharmacy: the chemistry of Rhenium and Technetium
- Metallosomes as CO releasing molecules
Liposomes are currently in common use as universal drug carriers. The manipulation of different physicochemical properties of these macromolecular aggregates enables the design of particular carriers with the desired properties. In recent years it has been corroborated that at certain levels, CO is a useful therapeutic agent with beneficial effects as anti-inflammatory, in cardiovascular diseases and also in organ transplantation. One interesting family of compounds, without precedents, that can be used as CO releasing molecules are metallosurfactants. Our current studies are focused to the preparation and characterization of mixed systems constituted by phospholipids and molybdenum carbonylic metallosurfactants (metallosomes). Depending on the phospholipid to metallosurfactant ratio, vesicles or micelles are obtained. These nanostructured systems are kinetically stabilized, and are being evaluated in order to assess their potential use as carbon monoxide releasing systems.